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Contraception masculine
par testostérone injectable

Juillet 2009

L´injection de 500 mg de testostérone est administrée chaque mois pendant 30 mois. On considére qu´une oligospermie sévère (moins de 1 million par ml) était un critère de suppression de la spermatogenèse
Elle semble donc donner une contraception efficace, réversible et fiable dans une proportion importante d´hommes chinois, fertiles, en bonne santé


Multicenter Contraceptive Efficacy Trial
of Injectable Testosterone Undecanoate in Chinese Men

Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2008-1846
Yiqun Gu, Xiaowei Liang, Weixiong Wu, Minli Liu, Shuxiu Song, Lifa Cheng, Liwei Bo, Chengliang Xiong, Xinghai Wang, Xiaozhang Liu, Lin Peng and Kangshou Yao

Context: Hormonal male contraceptive regimens effectively and reversibly suppress sperm production, but there are few large-scale efficacy studies.

Objective: The safety, contraceptive efficacy, reversibility, and feasibility of injectable testosterone undecanoate (TU) in tea seed oil as a hormonal male contraceptive was assessed.

Design: This was a multicenter, phase III, contraceptive efficacy clinical trial.

Participants: A total of 1045 healthy fertile Chinese men were recruited throughout China into the study.

Intervention(s): Injections of 500 mg TU were administered monthly for 30 months. A definition of severe oligozoospermia (?1 x 106/ml) was used as a criterion of spermatogenic suppression and as the threshold for entering the contraceptive efficacy phase.

Main Outcome Measure(s): The primary outcome was pregnancy rate in the partner. Other outcomes include: semen parameters, testis volumes, reproductive hormone levels, and safety laboratory tests.

Results: Forty-three participants (4.8%) did not achieve azoospermia or severe oligozoospermia within the 6-month suppression phase. A total of 855 participants entered into the efficacy phase, and 733 participants completed monthly TU treatment and follow-up.
There were nine pregnancies in 1554.1 person-years of exposure in the 24-month efficacy phase for a cumulative contraceptive failure rate of 1.1 per 100 men. The combined method failure rate was 6.1%, comprising 4.8% with inadequate suppression and 1.3% with postsuppression sperm rebound.
No serious adverse events were reported. Spermatogenesis returned to the normal fertile reference range in all but two participants.

Conclusions: Monthly injection of 500 mg TU provides safe, effective, reversible, and reliable contraception in a high proportion of healthy fertile Chinese men.
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