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Association of Proton Pump Inhibitors
With Risk of Dementia

A Pharmacoepidemiological Claims Data Analysis
Willy Gomm, PhD1; Klaus von Holt, MD, PhD1; Friederike Thomé, MSc1; Karl Broich, MD2; Wolfgang Maier, MD1,3; Anne Fink, MSc1,4; Gabriele Doblhammer, PhD1,4,5,6; Britta Haenisch, PhD1
JAMA Neurol. [Source]

Importance Medications that influence the risk of dementia in the elderly can be relevant for dementia prevention. Proton pump inhibitors (PPIs) are widely used for the treatment of gastrointestinal diseases but have also been shown to be potentially involved in cognitive decline.

Voir également : Effets indésirables des traitements prolongés par IPP

MAJ Février 2016
JAMA Neurol - (Source : [medicalement-geek.blogspot.com]
Une étude de cohorte prospective allemande à retrouvé que chez des patients de plus de 75 ans, le risque de démence était augmenté de 44% en cas de traitement par IPP.
Une raison de plus pour réévaluer régulièrement leurs prescriptions.

Objective
To examine the association between the use of PPIs and the risk of incident dementia in the elderly.

Design, Setting, and Participants
We conducted a prospective cohort study using observational data from 2004 to 2011, derived from the largest German statutory health insurer, Allgemeine Ortskrankenkassen (AOK). Data on inpatient and outpatient diagnoses (coded by the German modification of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision) and drug prescriptions (categorized according to the Anatomical Therapeutic Chemical Classification System) were available on a quarterly basis.
Data analysis was performed from August to November 2015.

Exposures
Prescription of omeprazole, pantoprazole, lansoprazole, esomeprazole, or rabeprazole.

Main Outcomes and Measures
The main outcome was a diagnosis of incident dementia coded by the German modification of the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision. The association between PPI use and dementia was analyzed using time-dependent Cox regression. The model was adjusted for potential confounding factors, including age, sex, comorbidities, and polypharmacy.

Results
A total of 73679 participants 75 years of age or older and free of dementia at baseline were analyzed. The patients receiving regular PPI medication (n=2950; mean [SD] age, 83.8 [5.4] years; 77.9% female) had a significantly increased risk of incident dementia compared with the patients not receiving PPI medication (n=70729; mean [SD] age, 83.0 [5.6] years; 73.6% female) (hazard ratio, 1.44 [95% CI, 1.36-1.52]; P<.001).

Conclusions and Relevance
The avoidance of PPI medication may prevent the development of dementia. This finding is supported by recent pharmacoepidemiological analyses on primary data and is in line with mouse models in which the use of PPIs increased the levels of ß-amyloid in the brains of mice. Randomized, prospective clinical trials are needed to examine this connection in more detail.
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